
After you have been ordered to have a biopsy, if or when diagnosed with Breast Cancer, the sample of the tumor will be provided to a pathologist. The pathologist may examine the breast cancer tumor underneath an advanced microscope, so that they he or she can determine if the tumor is malignant or benign. A pathologist is a doctor that is specially trained to examine tissue that is removed from biopsys, and then determines the results of the test and gives them to your physician, in order to help decide on the beast treatment for your case.
Determining whether the cancer cells have grown inside of the ducks or lobules or have started to spread to other distant parts of the body, or have began to get inside of the lining of the surrounded tissue of the breast, is a very important matter. The difference between the cancer cells being “in situ” or “invasive” will determine two totally different treatments. Invasive Cancer is much more serious than “in siti” cancer, which means “in place”.
Finding out if the Hormone Receptors test Positive - On the surface of cells, receptors are in place, that stick on to substances such as hormones, progesterone, or estrogen. The receptors act like when you use a key when you are trying to activate a lock, as you put the key in place. The cell is activated when it binds to the hormone, which makes it divide.
When you are tested ER Positive, it means that that tumor has tested positive for progesterone or estrogen receptors. ER positive means that you your test results came back as Estrogen Receptor Positive, Hormone Receptor Positive, or Progesterone Receptor Positive. It is very important to have these test results so your physician can precribe drugs that can help block the hormone action. The tumors that are not most likely not going to be able to respond to anti-estrogen therapy are tumors that have no estrogen or progesterone receptors.
Now lets talk about something called HER-2, which my mother tested positive for, which is an oncogene that is a gene that is connected to the development of certain cancers. Woman tend to develop more aggressive breast cancer, when they have a higher than normal level of oncogene named HER-2/Neu in their body. Your doctor will test your levels of HER-2, along with help from your oncologist, to decide if you could be a candidate for such cancer fighting drugs, such as Xeloda with Tykerb, or another popular cancer drug called Herceptin. My mother was precribed Herceptin as well, during her treatment, which ended helping her breast cancer treatment.
There are new tests that can be done now, where a tissue sample of the tumor can evaluate many numbers of genes, which is important in determining whether a tumor in particular will respond to treatment.
In many cases, the gene assay measures the chances of any distant breast cancer recurrance happening, and will also help your team of health-care professionals determine if chemotherapy should be a choice for you and your treatment, depending on your specific case.
The Growth Rate of tumors happen when cells divide and go through many phases. S-phase is when DNA begins to replicate itself, so each new copy of itself will go to every new cell. Rapid Tumor Growth is indicated when the percentage of cells are very high in the S-phase, which makes the tumor become more dangerous.
Ploidy- Chromosomes are a long strand of clustered DNA genes that have been stung together, which make up a blue print that determines how a cell works and what a cell does. When chromosomes are at an abnormal number in cells, they are called aneuploid. This basically means that this could mean a worse prognosis.
Some woman have heard of “Triple Negative Breast Cancer”, but still do not know exactly what this type of breast cancer is. Triple Negative Breast Cancer is when the tumor is tested negative for estrogen receptors, HER-2, or progesterone receptors, and mean that this cancer does not respond to hormonal therapy like tamoxifen or even aromatase inhibitors, or therapys such as Herceptin. In out of ten woman with breast cancer, one out of these ten will be tested positive for Triple Negative Breast Cancer, and will have to use other types of medicines.

Additional tests are needed for the pathologist to study, in order to determine what stage of Breast Cancer you have, such as a MRI, BSGI, CAT scan, CT scan, Bone Scan, and Pet Scan. Speak with you health care professional about your case and what testing they believe you should have, in order to have an accurate staging of your breast cancer. You can find out more about each of these tests on another blog I wrote, called ” Pathology reports and additional testing after biopsys ” the link to this blog is below.
http://breastcancerawareness.net/pathology-reports-and-additional-testing-after-biopsys-540.html
The Stages of Breast Cancer
Stage 0 – Stage 0 is a breast cancer that is Non-Invasive, and where no cancer cells have penetrated the lobule or ducks lining.
Stage 1 – Stage 1 breast cancer is when the tumor is Invasive, where the size of the tumor is 2 cm or smaller. Stage one breast cancer is when the Axillary lymph nodes have tested negative and there has been no showing of any distant metastases.
Stage 2 – Stage 2 breast cancer is when the tumor size is between 2 – 5 cm, and the axillary lymph nodes could or could not be positive for cancer. Even though the tumor itself may be smaller than 2 cm, it is always considered to be a stage 2 cancer, if the lymph nodes are tested positive.
Stage 3 – Stage 3 breast cancer is when the tumor is larger than 5 cm or 2 inches, where there is extensive lymph node spreading, and the tumor can extend inside of the pectoral muscle or the breasts skin, even when there are no distant metastases.
Stage 4 – Stage 4 breast cancer is when the tumor has spread to organs inside the body, usually the liver, lungs, bones, and brain, no matter what size the tumor is, or of the number of axillary lymph nodes tested positive.

TNM- Tumor, Node, Metastasis - the staging system. Staging is based on the size of the tumor; metastasis, or spreading of cancer cells to other organs in the body; presence of cancer cells inside of the lymph nodes.
The Tumor size is determined once it is removed and examined by a pathologist. An expert in tumors.
Your Lymph nodes will be examined to determine if there is any cancer or tumor spread during the time of surgery, using a procedure called “Axillary Lymph Node Dissection”.
Bone Scans, Blood Tests, CAT Scans, and X-Rays, will determine if any Metastasis, or spreading to any of the organs in your body has occured. When all of this information is gathered, it is the Process of Staging.
